The starring cast of Treme consists of thirteen actors.
- Khandi Alexander as LaDonna Batiste-Williams
- Rob Brown as Delmond Lambreaux
- Kim Dickens as Janette Desautel
- Melissa Leo as Antoinette Bernette
- Lucia Micarelli as Annie Talarico
- Clarke Peters as Albert Lambreaux
- Wendell Pierce as Antoine Batiste
- Steve Zahn as Davis McAlary
- Michiel Huisman as Sonny
- India Ennenga as Sofia Bernette
- David Morse as Terry Colson
- Jon Seda as Nelson Hidalgo
- Chris Coy as L.P. Everett
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